GLP-1 medications are changing how millions of people approach weight loss — but the options, costs, and clinical realities can be overwhelming. We break it all down, simply and honestly.
GLP-1 stands for glucagon-like peptide-1 — a hormone your body naturally produces after eating. It signals your brain that you're full, slows digestion, and helps regulate blood sugar.
GLP-1 receptor agonists are medications that mimic this hormone — but much more powerfully and for much longer. The result: significantly reduced appetite, slower stomach emptying, and meaningful, sustained weight loss for most people who use them consistently.
See which programs offer GLP-1 medications →Average body weight lost with semaglutide over 68 weeks in clinical trials
Average weight loss seen with tirzepatide (Zepbound) — the strongest GLP-1 available
Americans currently using a GLP-1 medication for weight management
Lowest monthly cost through telehealth programs using compounded semaglutide
These names get used interchangeably, but they're not the same. Here's a plain-language breakdown of every major GLP-1 option.
The gold standard for weight loss. FDA-approved specifically for chronic weight management. Trials show ~15% body weight reduction on average.
FDA-Approved · Weight LossSame active ingredient as Wegovy, approved for Type 2 diabetes. Widely prescribed off-label for weight loss — often when Wegovy supply is limited.
Off-Label Weight UseThe newest FDA-approved option. Works on two receptors (GIP + GLP-1), producing up to 22% body weight loss — the highest of any approved drug.
Strongest Results · FDA-ApprovedMade by licensed compounding pharmacies. Same active ingredient, 30–60% cheaper. Most telehealth programs use compounded versions to keep costs down.
Most Affordable OptionA short intake form about your health history, current medications, and weight goals. Takes 5–10 minutes and is done entirely online.
A doctor or nurse practitioner reviews your intake and consults with you — via video call or async messaging — to determine if GLP-1 therapy is appropriate for you.
If approved, your prescription goes to a licensed pharmacy and arrives within a few days. Most programs include monthly check-ins to adjust your dose as needed.
These are the questions we see most from people who are just starting to explore GLP-1 options.
See all programs →See all programs side by side — pricing, medication type, support, and our top picks.
Medical Disclaimer: WeightShots.com is an independent comparison and information website. We are not a medical provider and do not offer medical advice, diagnosis, or treatment. All content is for informational purposes only. Always consult a qualified healthcare professional before starting any medication or weight loss program. Affiliate Disclosure: This site contains affiliate links. We may earn a commission if you click a link and sign up for a program, at no additional cost to you. This does not influence our rankings or recommendations.